The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Computerized Video Time-Lapse Microscopy Studies of Ionizing Radiation-Induced Rapid-Interphase and Mitosis-Related Apoptosis in Lymphoid Cells
Abstract
Computerized video time-lapse (CVTL) microscopy of X-irradiated cultures of cells of the murine lymphoma cell lines ST4 and L5178Y-S and the human lymphoid cell line MOLT-4 demonstrated that these cells exhibit a wide disparity in the timing of induction and execution of radiation-induced cell death that included rapid-interphase apoptosis, delayed apoptosis, and postmitotic apoptosis. ST4 cells that received 2.5 or 4 Gy of X radiation underwent rapid-interphase apoptosis within 2 h. Apoptosis commenced with a 10-20-min burst of membrane blebbing followed by swelling for 2-4 h and cell collapse. No apoptotic bodies were formed. After a dose of 1 Gy, approximately 90% of ST4 cells died by rapid-interphase apoptosis, while the remainder completed several rounds of cell division prior to cell death. Postmitotic death of ST4 cells occurred with the same morphological sequence of events as during rapid-interphase apoptosis induced by doses of 1-4 Gy. In contrast, L5178Y-S and MOLT-4 cells that received 4 Gy underwent apoptosis more slowly, with a complex series of events occurring over 30-60 h. Only 3% of L5178Y-S cells and 24% of MOLT-4 cells underwent apoptosis without attempting cell division. The cells became abnormally large during a long G(2)-phase delay, and then most of the cells (76-97%) attempted to divide for the first or second time at approximately 18-30 h postirradiation. However, either mitosis failed or division was aberrant; i.e., the large cells divided into three or four fragments which eventually fused together. This process was followed by several rounds of complex and unpredictable membrane blebbing, gross distortions of shape, fragmentation-refusion events, and formation of apoptotic bodies, after which the cells collapsed at 36-60 h postirradiation.
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“During this process, the cell membrane ruptured, and many small membrane blebs formed, resembling post-mitotic apoptotic cell death (13).”
From Disruption of cancer cell replication by alternating electric fields (2004) · cites this paper as [13]
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Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,980
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803
Thymocyte apoptosis induced by p53-dependent and independent pathways
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271
p53 mutations in colorectal cancer.
Rodrigues, N. R., Rowan, A., Smith, M. E., Kerr, I. B., Bodmer, W. F., Gannon, J., & Lane, D. P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7555 · Cited by 1,002
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
Sellins, K. S., & Cohen, J. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.10.3199 · Cited by 919
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
Waldman, T., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1996) · Nature · doi:10.1038/381713a0 · Cited by 728
Apoptosis and cancer chemotherapy
Makin, G., & Dive, C. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02124-9 · Cited by 340
Cited by
The role of apoptosis in cancer development and treatment response
Brown, J. M., & Attardi, L. D. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1560 · Cited by 959
Disruption of cancer cell replication by alternating electric fields
Kirson, E. D., Gurvich, Z., Schneiderman, R., Dekel, E., Itzhaki, A., Wasserman, Y., Schatzberger, R., & Palti, Y. (2004) · Cancer research · doi:10.1158/0008-5472.can-04-0083 · Cited by 827
The linear quadratic model: usage, interpretation and challenges
McMahon, S. J. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aaf26a · Cited by 501
Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer
Sia, J., Szmyd, R., Hau, E., & Gee, H. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00041 · Cited by 378
New concepts in radiation‐induced apoptosis: ‘premitotic apoptosis’ and ‘postmitotic apoptosis’
Shinomiya, N. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00158.x · Cited by 120
Metadata
- Authors
- Endlich, B., Radford, I. R., Forrester, H. B., & Dewey, W. C.
- Affiliations
- Cleveland Clinic (US)
- Peter MacCallum Cancer Centre (AU)
- University of California, San Francisco (US)
- Corresponding author
- Endlich, Brian
- Venue
- Radiation Research
- Publisher
- Radiation Research Society
- Published
- 2000-01
- Volume
- 153
- Issue
- 1
- Pages
- 36-48
- ISSN
- 0033-7587 (ISSN-L)
- 1938-5404
- OpenAlex
- W2022524530
- Cited by
- 66
- References
- 34
- Citations by year
- 2024: 2 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 1 · 2014: 2 · 2013: 6 · 2012: 6
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiation Research (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- Cleveland Clinic Foundation
- National Institutes of Health (5r01ca031808-17)
- National Cancer Institute (CA-31808)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- radiation-induced apoptosis, X-ray irradiation, lymphoid cells, lymphoma cell lines, MOLT-4 cells, membrane blebbing, apoptotic bodies
- MeSH terms
- Animals, Dose-Response Relationship, Radiation, Flow Cytometry, Humans, Interphase, Lymphocytes, Lymphoma, Microscopy, Fluorescence, Mitosis, Time Factors, Tumor Cells, Cultured, X-Rays, Apoptosis, Microscopy, Video, Cell Lineage, Mice
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- CoChat. (2026). Citation check: Computerized Video Time-Lapse Microscopy Studies of Ionizing Radiation-Induced Rapid-Interphase and Mitosis-Related Apoptosis in Lymphoid Cells. https://app.cochat.ai/papers/10.1667/0033-7587(2000)153%5B0036:cvtlms%5D2.0.co;2
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- Endlich, B., Radford, I. R., Forrester, H. B., & Dewey, W. C. (2000). Computerized Video Time-Lapse Microscopy Studies of Ionizing Radiation-Induced Rapid-Interphase and Mitosis-Related Apoptosis in Lymphoid Cells. Radiation Research. https://doi.org/10.1667/0033-7587(2000)153%5B0036%3Acvtlms%5D2.0.co%3B2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
